The Speakers


James Krieger

Lyle Mcdonald

Webinar Outline


James's overview

1. Defining the problem

a. Different tendencies towards weight gain

b. Do slow & fast metabolisms explain weight change tendencies?

c. Reduced obese people and energy requirements


2. Components of energy expenditure


3. Where are the diminished energy requirements coming from?

a. RMR of reduced obese people

b. TEF of reduced obese people

c. Physical activity of reduced obese people



a. Variance between individuals

b. Role in resistance to fat gain

c. Typical energy expenditures of NEAT activities

d. Age

e. Weight loss

f.  Structured exercise

g. Societal impacts

h. Genetics

i. Biological regulation

j. Obese vs. lean

k. Improving NEAT

Lyle's overview

1. Defining the problem

a.  What is stubborn fat?

            b. When does stubborn fat become relevant for dieters?

c. Is targeting stubborn fat spot reduction?


2. What is bodyfat?

a. Adipocytes


c. Purpose ofbodyfat


3. Types of fat

a. Essential fat

b. Brown/Beige/Brite fat

c. Visceral fat

d. Subcutaneous fat

e. Stubborn Fat


4. Basic Fat Cell Metabolism

a. Hyperplasia, Hypertrophy, Apoptosis

b. Lipogenesis, Lipolysis

c. Dietary fat metabolism

d. Fat storage: LPL, ASP


5. Burning body fat

a. Breakdown and mobilization

b. Blood flow and transport

c. Uptake and oxidation


6. Hormones and body fat

a. Insulin

b. Glucagon

c. Catecholamines

d. Growth Hormone

e. Cortisol

f. Thyroid

g. Leptin

h. ANP

i. Sex hormones: testosterone, estrogen, progesterone


7. Why is stubborn fat stubborn?

a. Adrenoceptor ratios

b. Blood flow differences

c. Insulin sensitivity

d. Type of fatty acid storage

e. Fat cell size

f. Fat cell number

g. Global effects of dieting


8: Diet, Exercise, Supplements (Drugs?)

a. Low vs. high carb-diets

b. Aerobic exercise intensity: overcoming lipolytic resistance, effect of lactate

c. Yohimbine

d. Gender differences


9. The protocols

a. Low carb diet + low intensity aerobics

b. Oral yohimbe/yohimbine plus low intensity aerobic activity

c. SFP 1.0: HIIT + low intensity aerobic